Procurou por: Redox+Electrodes

Código de Artigo: (PRSI91-239)

Fornecedor: ProSci Inc.

Descrição: Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.

UOM: 1 * 50 µG

Promoção

Fornecedor: WTW

Descrição: Integratable adapters for connecting Multi IDS meters with conventional pH/ORP/ISE electrodes.

Fornecedor: VWR Collection

Descrição: Este instrumento fácil de usar, com um suporte para elétrodo articulado e caixa com grau de proteção IP 43, oferece alta resolução e exatidão para medições precisas. Inclui saída USB para ligação a um computador. Em conformidade com a norma BPL.

Fornecedor: WTW

Descrição: Analog conductivity measuring cells for wastewater are to be connected to analog transmitters.

Fornecedor: VWR Collection

Descrição: These digital meters combine six parameters in one instrument: pH, mV, temperature, conductivity, dissolved oxygen and turbidity. IDP technology optimises use and makes measurement easier (no need to recalibrate when changing the meter and no need to adjust the meter’s settings). The measured data is complete with serial number, settings and calibration data.

Código de Artigo: (663-0147)

Fornecedor: VWR Collection

Descrição: Eléctrodo, condutividade, VWR® pHenomenal®, pHenomenal® CO11, 10 µS/cm - 20 mS/cm, 0...+80 °C, Epóxi, Ø×C: 15,3×120 mm, 0,84 cm^-1, 8 pinos, cabo de 1,5 m

UOM: 1 * 1 unid.

Promoção

Código de Artigo: (PRSI92-247)

Fornecedor: ProSci Inc.

Descrição: TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The molecular cloning and characterisation of one member of the thioredoxin superfamily, designated as TMX2.The TMX2 cDNA consists of 1644 nucleotides and contains an open reading frame encoding a protein of 372 amino acids with a predicted molecular mass of 42.5 kDa and an isoelectric point of 8.94. The TMX2 protein may possess an N-terminal signal peptide, a potential transmembrane domain, an Myb DNA-binding domain repeat signature, a thioredoxin consensus pattern, an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif), and a dileucine motif in the tail.

UOM: 1 * 50 µG

Promoção

Código de Artigo: (700-0799)

Fornecedor: VWR Collection

Descrição: The 'Revolution' series includes a buffer circulation system, powered by the electrodes themselves. Hydrogen bubbles produced at the cathode pass up a diagonally positioned pipe connected to the two sides of the tank producing a gentle circulation of the buffer. The result is no pH and ionic gradient – without need of mechanical pumps.

UOM: 1 * 1 unid.

Promoção

Código de Artigo: (BOSSBS-2766R-A750)

Fornecedor: Bioss

Descrição: FOXO1 is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

UOM: 1 * 100 µl

Promoção

Código de Artigo: (662-2132)

Fornecedor: WTW

Descrição: Medidor de pH, Kit QSC, kit de calibração inicial para elétrodos de pH IDS (caixa com 3 ampolas: pH 4,01/pH 6,86/pH 9,18)

UOM: 1 * 1 unid.

Certificados Promoção

Fornecedor: WTW

Descrição: Medidores multiparamétricos portáteis e compactos para medições de pH, condutividade e oxigénio dissolvido com sensores digitais inteligentes (IDS). Possuem um canal de medição universal para todos os parâmetros. O design robusto e impermeável torna-os ideais para medições de campo e no laboratório.

Fornecedor: VWR Collection

Descrição: Medidores de pH económicos, robustos e impermeáveis fornecidos em conjuntos prontos a usar que incluem uma caixa de transporte robusta, elétrodo e sonda de temperatura com cabos de diferentes comprimentos e tampões.

Código de Artigo: (BOSSBS-1306R-A750)

Fornecedor: Bioss

Descrição: Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteines, arginines and lysines residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785). Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function (PubMed:17015834, PubMed:20304780, PubMed:18711745, PubMed:12796482, PubMed:19229105, PubMed:25416785). It is involved in neuroprotective mechanisms like the stabilisation of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway (PubMed:12612053, PubMed:15502874, PubMed:14749723, PubMed:17015834, PubMed:21097510, PubMed:18711745). Its involvement in protein repair could also explain other unrelated functions. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death (PubMed:16390825). Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria (PubMed:19229105, PubMed:16632486). Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking (PubMed:18711745). Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (PubMed:23847046).

UOM: 1 * 100 µl

Promoção

Código de Artigo: (WTWA1FD680)

Fornecedor: WTW

Descrição: Gateway with REST API interface for the allocation of data records. Suitable for pH, ORP, conductivity and dissolved oxygen of IDS wireless sensors.

UOM: 1 * 1 unid.

Promoção

Código de Artigo: (115-0128)

Fornecedor: VWR Collection

Descrição: These non woven wipes are constructed from 100% polypropylene and are moistened with a blend of pure, reagent grade 70% isopropyl alcohol and 30% reagent grade deionised water. They are ideal for wiping optical parts, delicate glassware, electrodes, cuvettes, microscopes or lenses.

UOM: 1 * 100 unid.

MSDS Promoção

Código de Artigo: (PRSI92-690)

Fornecedor: ProSci Inc.

Descrição: Human serum albumin (HSA), the most abundant protein in human blood plasma, is essential for maintaining osmotic pressure. It is produced in the liver, consists of a single polypeptide chain, with 585 amino acids with 17 tyrosil residues and one tryptophan located in position 214. HSA is organised in three domains, I, II and III, each consisting of two subdomains, A and B. In the physiological states, HSA occurs in two forms – the non-modified HSA with a free thiol group of Cys-34, and the modified (oxidised) form (oHSA), also called human mercaptoalbumin (HMA) and human nonmercaptoalbumin (HNA), respectively. HMA and HNA are in equilibrium, depending on the redox state of Cys-34, and their ratio also varies depending on age and the diseased state. HSA functions primarily as a carrier protein for drugs, steroids, fatty acids, and thyroid hormones, and plays a role in stabilising extracellular fluid volume.

UOM: 1 * 50 µG

Promoção