Procurou por: Tonbo Biosciences

Código de Artigo: (40-1522-U100)

Fornecedor: Tonbo Biosciences

Descrição: The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (60-4031-U100)

Fornecedor: Tonbo Biosciences

Descrição: The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (55-4321-U100)

Fornecedor: Tonbo Biosciences

Descrição: The 2A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2a antibodies.

UOM: 1 * 100 µG

Promoção

Fornecedor: Tonbo Biosciences

Descrição: The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation. The 2H7 antibody is reported to be cross-reactive with several non-human species including Baboon, Chimpanzee, Cynomolgus and Rhesus. Please choose the appropriate format for each application.

Fornecedor: Tonbo Biosciences

Descrição: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Fornecedor: Tonbo Biosciences

Descrição: The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB. The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages and granulocytes. The antibody is reported to be cross-reactive for Chimpanzee CD45RO.

Fornecedor: Tonbo Biosciences

Descrição: The HIT2 antibody is specific for human CD38, a 45 kD type II transmembrane glycoprotein expressed on thymocytes, activated T and B cells, and monocytes as well as other non-hematopoietic cells. CD38 is an ectoenzyme that functions to catalyze the synthesis and hydrolysis of cyclic ADP-ribose and is involved in cell signaling, regulating cell adhesion, and activation. Additionally, CD38 has been shown to be a prognostic marker for some leukemias and other diseases.

Fornecedor: Tonbo Biosciences

Descrição: The M1/69 antibody reacts with mouse CD24, a cell surface molecule also known as Heat Stable Antigen (HSA). CD24 is a GPI-linked glycoprotein involved in cell adhesion and is a ligand for CD62P (P-selectin). It is expressed on erthrocytes, thymocytes, peripheral lymphocytes and myeloid lineage cells. The expression of CD24 is used to delineate stages of of lymphocyte development in the bone marrow.

Fornecedor: Tonbo Biosciences

Descrição: The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

Fornecedor: Tonbo Biosciences

Descrição: The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.

Fornecedor: Tonbo Biosciences

Descrição: The L17F12 antibody is specific for human CD5, a 67 kD transmembrane glycoprotein that is expressed on most thymocytes, mature T cells, and a subset of B cells. CD5 is a member of the scavenger receptor superfamily and is present on approximately 70% of normal peripheral blood lymphocytes. CD5 is involved in modulating antigen receptor signaling in both T and B cells and acts through binding of CD72, its receptor expressed on B cells.

Fornecedor: Tonbo Biosciences

Descrição: The 2H7 antibody reacts with human CD20, expressed by pre-B cells, resting and activated B cells, follicular dendritic cells and a small subset of T cells, but not on plasma cells. CD20 is a 33-37 kDa transmembrane protein which is differentially phosphorylated in resting and active B cells. The CD20 molecule plays a role in regulating B-cell activation.

Fornecedor: Tonbo Biosciences

Descrição: The L17F12 antibody is specific for human CD5, a 67 kD transmembrane glycoprotein that is expressed on most thymocytes, mature T cells, and a subset of B cells. CD5 is a member of the scavenger receptor superfamily and is present on approximately 70% of normal peripheral blood lymphocytes. CD5 is involved in modulating antigen receptor signaling in both T and B cells and acts through binding of CD72, its receptor expressed on B cells.

Certificados

Fornecedor: Tonbo Biosciences

Descrição: The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Código de Artigo: (TNB-4300-L100)

Fornecedor: Tonbo Biosciences

Descrição: RBC Lysis Buffer (10X) is a concentrated ammonium chloride-based lysing reagent.

UOM: 1 * 100 mL

Certificados Promoção

Fornecedor: Tonbo Biosciences

Descrição: The 104 antibody reacts with mouse CD45.2, also known as Ly5.2, which is a strain-specific allelic form of the CD45 Leukocyte Common Antigen (LCA). Functionally, CD45 is a protein tyrosine phosphatase whose broad cell distribution supports a critical role in many leukocyte functions, including regulation of signal transduction and cell activation associated with the T cell and B cell receptors.