Procurou por: ENZO LIFE SCIENCES

Fornecedor: ENZO LIFE SCIENCES

Descrição: Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase.
ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.

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Código de Artigo: (ENZOALX804155C100)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNF-R1 and Fas, two prototype members in the death receptor family. A member in the RIP kinase family was identified and designated RIP3. RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues. Meanwhile RIP4 has been identified and initially characterized. These data suggest that RIP4 is involved in NF-κB and JNK signalling and that caspase-dependent processing of RIP4 may negatively regulate NF-κB-dependent pro-survival or pro-inflammatory signals.

UOM: 1 * 100 µG

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Fornecedor: ENZO LIFE SCIENCES

Descrição: Immunosuppressant. Isolated from<i> Penicillium brevicompactum.</i>

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Código de Artigo: (ENZOBMLHO0130050)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Inhibits thromboxane production in human platelets

UOM: 1 * 50 µG

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Fornecedor: ENZO LIFE SCIENCES

Descrição: Suppresses activation of platelets. Induces endothelial injury. Constricts isolated coronary arteries. Inhibits prostacyclin synthase.

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Código de Artigo: (ENZOBMLIG60600100)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µl

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Código de Artigo: (ENZOALX805076C100)

Fornecedor: ENZO LIFE SCIENCES

Descrição: CEACAM1 (CD66a, BGP) belongs to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAMs.

UOM: 1 * 100 µG

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Código de Artigo: (ENZOALX850247KI01)

Fornecedor: ENZO LIFE SCIENCES

Descrição: The assay utilizes bioluminescent detection of the ATP level for a rapid screening of apoptosis and cell proliferation simultaneously in mammalian cells. The assay utilizes the enzyme luciferase to catalyze the formation of light from ATP and luciferin. The light can be measured using a luminometer or Beta Counter. The assay can be fully automatic for high throughput (10 seconds/sample) and is highly sensitive (detects 10-100 mammalian cells/well).

UOM: 1 * 200 Tests

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Código de Artigo: (ENZOALX850064KI01)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Can be used to activate human B cells and dendritic cells. Stimulates growth of human B cells. For stimulation of mouse cells via CD40 use MAb to CD40 (mouse) (FGK45) (Prod. No. ALX-805-046).

UOM: 1 * 1 SET

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Código de Artigo: (ENZOALX850214KI01)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Based on the detection of AFC (7-amino-4-trifluoromethyl coumarin) after cleavage from the labelled substrate VDVAD-AFC.

UOM: 1 * 25 Tests

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Código de Artigo: (ENZOALX850227KI01)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Synthetic peptides that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1/ICE, VDVAD is the recognition sequence for caspase-2, DEVD is the recognition sequence for caspase-3/CPP32, WEHD is the recognition sequence for caspase-5, VEID is the recognition sequence for caspase-6/Mch2, IETD is the recognition sequence for caspase-8/FLICE, LEHD is the recognition sequence for caspase-9, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.

UOM: 1 * 1 SET

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Fornecedor: ENZO LIFE SCIENCES

Descrição: eNOS activator

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Código de Artigo: (ENZOALX151041M005)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Angiotensin I/II (1-7)

UOM: 1 * 5 mg

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Código de Artigo: (ENZOBMLP2350001)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Fluorogenic substrate for ADAM8 (kcat/Km = 1,0×105 M-1s-1), ADAM10 (6,2×103), ADAM12 (2,8×105), TACE (TNF-α converting enzyme, ADAM17) (4,3×105), and likely other ADAMs, especially those that cleave TNF-α type sequences. Also efficiently cleaved by MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, and MMP-14. FAM fluorescence is quenched by the Dabcyl group until cleavage separates them. Ex.: 485 nm, Em.: 530 nm. This substrate is useful for inhibitor screening and kinetic analysis.

UOM: 1 * 1 mg

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Código de Artigo: (ENZOBMLP2480001)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Protein kinase substrate

UOM: 1 * 1 mg

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Código de Artigo: (ENZOBMLP2320001)

Fornecedor: ENZO LIFE SCIENCES

Descrição: AMPK substrate

UOM: 1 * 1 mg

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