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Image Unavailable-BOSSBS-5691R-A555

Anti-RAB24 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Código de Artigo: (BOSSBS-5691R-A555)
Fornecedor: Bioss
Descrição: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5691R-A647

Anti-RAB24 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Código de Artigo: (BOSSBS-5691R-A647)
Fornecedor: Bioss
Descrição: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-CY5.5

Anti-NEDD4 Rabbit Polyclonal Antibody (Cy5.5®)

Código de Artigo: (BOSSBS-7877R-CY5.5)
Fornecedor: Bioss
Descrição: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Imagem do Produto-LBCP7205101

Accessories for FreeZone® freeze drying systems

Fornecedor: LABCONCO
Descrição: Fast-Freeze® flasks for FreeZone® freeze dry systems are designed to be easier to handle, faster to load, and more convenient to use in the laboratory for freeze drying.

Environmentally Preferable

Imagem do Produto-710-0580

Micro ESD swabs, Alpha®

Código de Artigo: (710-0580)
Fornecedor: Texwipe
Descrição: Swab head features ultra-clean, laundered, double layer knitted Alpha polyester with flexible internal paddle.
UOM: 1 * 500 unid.
Image Unavailable-BOSSBS-7877R-HRP

Anti-NEDD4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Código de Artigo: (BOSSBS-7877R-HRP)
Fornecedor: Bioss
Descrição: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-CY3

Anti-NEDD4 Rabbit Polyclonal Antibody (Cy3®)

Código de Artigo: (BOSSBS-7877R-CY3)
Fornecedor: Bioss
Descrição: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0676R-CY5

Anti-FGFR4 Rabbit Polyclonal Antibody (Cy5®)

Código de Artigo: (BOSSBS-0676R-CY5)
Fornecedor: Bioss
Descrição: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9060R-A555

Anti-DVL2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Código de Artigo: (BOSSBS-9060R-A555)
Fornecedor: Bioss
Descrição: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13004R-FITC

Anti-DVL2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Código de Artigo: (BOSSBS-13004R-FITC)
Fornecedor: Bioss
Descrição: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9060R

Anti-DVL2 Rabbit Polyclonal Antibody

Código de Artigo: (BOSSBS-9060R)
Fornecedor: Bioss
Descrição: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5691R-CY5.5

Anti-RAB24 Rabbit Polyclonal Antibody (Cy5.5®)

Código de Artigo: (BOSSBS-5691R-CY5.5)
Fornecedor: Bioss
Descrição: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1243R-A647

Anti-TROP2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Código de Artigo: (BOSSBS-1243R-A647)
Fornecedor: Bioss
Descrição: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5350R

Anti-FLNA Rabbit Polyclonal Antibody

Código de Artigo: (BOSSBS-5350R)
Fornecedor: Bioss
Descrição: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
UOM: 1 * 100 µl
Imagem do Produto-611-3363

VWR® LP series, Balanças de precisão

Fornecedor: VWR Collection
Descrição: As balanças robustas e económicas são ideais para estabelecimentos de ensino e uso laboratorial. Uma série que inclui desde a pesagem simples até ao funcionamento com calibração interna automática e a funcionalidade de data/hora de BPL. Modelos com prato de pesagem em aço inoxidável.

Image Unavailable-BOSSBS-2162R-CY7

Anti-DKK1 Rabbit Polyclonal Antibody (Cy7®)

Código de Artigo: (BOSSBS-2162R-CY7)
Fornecedor: Bioss
Descrição: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
UOM: 1 * 100 µl
Preço sob consulta
O stock para este item é limitado. Por favor, certifique-se de que efetuou o seu login para visualizar o stock disponível. Se a call ainda é exibida e precisar de ajuda, por favor, ligue para 213 600 770
O stock para este item é limitado. Por favor, certifique-se de que efetuou o seu login para visualizar o stock disponível. Se a call está visível e precisar de ajuda, por favor, ligue para 213 600 770
Este produto é sujeito a regulamentação especifica.
Em caso de encomenda, será contactado a solicitar documentação complementar necessária e/ou obrigatória (licença, autorização ou declaração de uso final) para a continuidade do pedido. Agradecemos a vossa compreensão
Este produto é sujeito a regulamentação especifica.
Em caso de encomenda, será contactado a solicitar documentação complementar necessária e/ou obrigatória (licença, autorização ou declaração de uso final) para a continuidade do pedido. Agradecemos a vossa compreensão.
Este produto está bloqueado. Para obter mais informações, contacte a VWR através do número 213 600 770.
O produto pretendido já não se encontra disponível. O produto indicado é um substituto.
Este produto encontra-se em rutura de stock. Poderá encontrar alternativas pesquisando pelo código de artigo indicado acima. Se precisar de ajuda, por favor contacte a VWR através do 213 600 770.
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