Procurou por: Akt+inhibitor+VIII

Código de Artigo: (PRSI96-291)

Fornecedor: ProSci Inc.

Descrição: Fatty acid-binding protein 3 (FABP3) is also known as Heart-type fatty acid binding protein (H-FABP), Mammary-derived growth inhibitor (MDGI), Muscle fatty acid-binding protein (M-FABP), FABP11, which belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. H-FABP / FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABP3 may also contribute to AS160 phosphorylation by maintaining insulin-dependent Akt activation in the cells under a lipotoxic condition.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (PRSI3521)

Fornecedor: ProSci Inc.

Descrição: IRS-1 Antibody: Following tyrosine phosphorylation, the insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) can form a protein scaffolding for the assembly of a host of Src homology 2 (SH2) domain-containing proteins. IRS-1 tyrosine phosphorylation can occur through the activity of several cytokine and growth factor receptors such as interleukin (IL)-4, IL-9, interferon-gamma, in addition to the insulin and insulin-like growth factor 1 receptors. The scaffolding provided by IRS-1 and IRS-2 is necessary for insulin signal transduction across the cell membrane. IRS-1 tyrosine phosphorylation, and thus formation of the IRS scaffolding is inhibited by tumor necrosis factor (TNF), and this inhibition can itself be blocked by rapamycin, an inhibitor of the mammalian target of rapamycin (TOR). TNF activity could also be blocked by inhibition of the Akt kinase and the PTEN tumor suppressor, suggesting that TNF impairs insulin signaling through IRS-1 by activation of the TOR signaling pathway.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (PRSI33-139)

Fornecedor: ProSci Inc.

Descrição: HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

UOM: 1 * 100 µG

Novo produto Promoção

Código de Artigo: (62571-50MG-F)

Fornecedor: Merck

Descrição: Lipophilic, neutral ionophore for lithium ion-selective solvent polymeric membrane electrodes.

UOM: 1 * 50 mg

Promoção

Código de Artigo: (PRSI96-410)

Fornecedor: ProSci Inc.

Descrição: Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (75633-2ML)

Fornecedor: SIGMA ALDRICH MICROSCOPY

Descrição: Osmium tetroxide solution has been used as a fixative in electron microscopy.

UOM: 1 * 2 mL

Promoção

Código de Artigo: (USBIF0016-10-1)

Fornecedor: US Biological

Descrição: Anti-Factor VIII, Human Sheep Polyclonal Antibody

UOM: 1 * 1 mg

Promoção

Código de Artigo: (USBI144373)

Fornecedor: US Biological

Descrição: Anti-Coagulation factor VIII Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

Promoção

Código de Artigo: (87047.180)

Fornecedor: VWR Chemicals

Descrição: Multi-Element Standard, ICP multi-element standard solution VIII, 24 elements, 100 mg/L each of Al; B; Ba; Be; Bi; Ca; Cd; Co; Cr; Cu; Fe; Ga; K; Li; Mg; Mn; Na; N ; Pb; Se; Sr; Te; Tl; Zn, VWR® ARISTAR®, Matriz: 2% HNO₃, Aplicação: Padrões para ICP

UOM: 1 * 100 mL

MSDS Certificados Promoção

Código de Artigo: (USBIV2700-04C)

Fornecedor: US Biological

Descrição: Anti-Factor VIII Related Antigen Rabbit Polyclonal Antibody

UOM: 1 * 1 mL

Promoção

Fornecedor: SIGMA ALDRICH MICROSCOPY

Descrição: Osmium tetroxide (OsO₄) is a heavy tetrahedral, symmetrical molecule composed of osmium, a third-row transition metal. Osmium tetroxide is both a dye, and a non-coagulant fixative agent in electron microscopy primarily used for the examination of biological tissue components in the histopathology laboratory. Specimens are postfixed with osmium testroxide to ensure preservation of the lipids.

Fornecedor: VWR Collection

Descrição: Acetal polymer. Suitable for holding and identifying large tissue samples in processing, embedding and sectioning procedures. Resistant to all commonly used histological solvents. Mega cassette with welded lid. Box of 100 cassettes.

Código de Artigo: (ABCAAB41188-100)

Fornecedor: Abcam

Descrição: Mouse Monoclonal Factor VIII antibody. Suitable for ELISA, WB and reacts with Human samples. Immunogen corresponding to Native Full Length Protein corresponding to Human F8.

UOM: 1 * 100 µG

Promoção

Fornecedor: Thermo Fisher Scientific

Descrição: Tetróxido de ósmio 2,5% (w/w) in tert-butanol estabilizada

MSDS

Fornecedor: Thermo Fisher Scientific

Descrição: Tetróxido de ósmio 4% (w/w) in water

MSDS

Código de Artigo: (USBIN0590-15D)

Fornecedor: US Biological

Descrição: Anti-Nei Endonuclease VIII-like 3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

Promoção