Procurou por: 5-Fluorouracil

Fornecedor: Merck

Descrição: 5-Fluoroorotic acid hydrate, Sigma-Aldrich®

Código de Artigo: (USBIF5050-500)

Fornecedor: US Biological

Descrição: 5-Fluoroorotic acid monohydrate (5-FOA)

UOM: 1 * 500 mg

Promoção

Fornecedor: Thermo Fisher Scientific

Descrição: Thermo Scientific 5-Fluoroorotic Acid (5-fluorouracil-6-carboxylic acid monohydrate; 5-FOA) is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate (OMP) dicarboxylase

Fornecedor: Merck

Descrição: 5-Fluoro-5'-deoxyuridine (Doxifluridine), Sigma-Aldrich®

Código de Artigo: (PRSI34-176)

Fornecedor: ProSci Inc.

Descrição: It recognises a protein of 36 kDa, identified as Thymidylate Synthase (TS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

Novo produto Promoção

Código de Artigo: (PRSI33-219)

Fornecedor: ProSci Inc.

Descrição: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

Novo produto Promoção

Fornecedor: MP Biomedicals

Descrição: FOA is a derivative of a pyrimidine precursor and is selectively toxic to yeast cells which synthesize orotidine-5’-phosphate decarboxylase. FOA has been used in a positive selection for uracil-requiring mutants(in the presence of large numbers of wild-type cells) lacking OMPdecase or OPRTase activities. This results in efficient strains for effective transformation systems.

Código de Artigo: (PRSI30-425)

Fornecedor: ProSci Inc.

Descrição: TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-47 CR601528.1 1-47 48-1099 X02308.1 14-1065 1100-1603 BC083512.1 1067-1570

UOM: 1 * 50 µG

Promoção

Código de Artigo: (PRSI47-129)

Fornecedor: ProSci Inc.

Descrição: Thymidylate synthase (TS) is anintracellular enzyme critical for de novosynthesis of DNA. In cancer,expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

UOM: 1 * 100 µG

Promoção

Código de Artigo: (PRSI33-918)

Fornecedor: ProSci Inc.

Descrição: Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

Novo produto Promoção

Código de Artigo: (PHR2867-50MG)

Fornecedor: Merck

Descrição: FLUOROURACIL RELATED COMPOUND E 1 * 50 mg

UOM: 1 * 50 mg

Promoção

Código de Artigo: (PHR2866-50MG)

Fornecedor: Merck

Descrição: FLUOROURACIL RELATED COMPOUND B 1 * 50 mg

UOM: 1 * 50 mg

Promoção

Código de Artigo: (PHR2865-50MG)

Fornecedor: Merck

Descrição: FLUOROURACIL RELATED COMPOUND A 1 * 50 mg

UOM: 1 * 50 mg

Promoção

Código de Artigo: (PHR2868-50MG)

Fornecedor: Merck

Descrição: FLUOROURACIL RELATED COMPOUND F 1 * 50 mg

UOM: 1 * 50 mg

Promoção

Código de Artigo: (CAYM20977-50)

Fornecedor: Cayman Chemical

Descrição: 5,6-DIHYDRO-5-FLUOROURACIL 1 * 50 mg

UOM: 1 * 50 mg

Promoção

Código de Artigo: (ABCAAB142387-1)

Fornecedor: Abcam

Descrição: 5-FLUOROURACIL 1 * 1 g

UOM: 1 * 1 g

Promoção