Procurou por: 171-0648++

Código de Artigo: (BOSSBS-9796R-A750)

Fornecedor: Bioss

Descrição: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf96 gene product has been provisionally designated C1orf96 pending further characterisation.

UOM: 1 * 100 µl

Promoção

Código de Artigo: (113-02999)

Fornecedor: FRISTADS KANSAS

Descrição: Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

UOM: 1 * 1 unid.

Promoção

Fornecedor: Thermo Fisher Scientific

Descrição: Acetato de cobalto (II) tetrahidratado ≥99.999% (baseado em metais)

MSDS

Código de Artigo: (BOSSBS-9380R-A750)

Fornecedor: Bioss

Descrição: Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterised by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.

UOM: 1 * 100 µl

Promoção

Código de Artigo: (BOSSBS-9380R-A680)

Fornecedor: Bioss

Descrição: Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterised by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. OS-I mutations produce proteins with a decreased affinity for microtubules.

UOM: 1 * 100 µl

Promoção

Código de Artigo: (1.10398.0500)

Fornecedor: Merck

Descrição: Dehydrated media are used for a wide variety of applications. To minimise the risks associated with powdered culture media, the majority of Merck's dehydrated culture media is produced in granular form. Merck uses ingredients of non animal origin to minimise the potential risk of transmissible spongiform encephalitis (TSE). When there is no alternative, only ingredients which are recommended by EDQM, and belonging to TSE category B or C are used. This ensures that the product is of the highest quality and in compliance with the standards for food control, microbiological testing on finished products and starting materials, and quality control in the pharmaceuticals and cosmetics industries. Custom-made media can be prepared to meet individual customer specifications. The formulation is kept confidential via a Non Disclosure Agreement. Please enquire for further details. Advantages of granulated Merck media.

UOM: 1 * 500 g

MSDS Certificados Promoção

Código de Artigo: (BOSSBS-9881R-A750)

Fornecedor: Bioss

Descrição: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine Signalling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

UOM: 1 * 100 µl

Promoção

Fornecedor: Merck

Descrição: Elix® Essential delivers Type 2 water customised to fit a broad range of research areas. It is designed to be fed from potable water and is the ideal feed for any laboratory equipment, including ultrapure water systems such as Milli-Q® systems.

Código de Artigo: (BOSSBS-9881R-A680)

Fornecedor: Bioss

Descrição: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine Signalling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

UOM: 1 * 100 µl

Promoção

Fornecedor: LABCON

Descrição: ProtectR® tube is the only container closure system engineered to be CO₂ resistant and stop costly damage to molecular and cellular solutions when using dry ice. Made of durable, high-quality materials and fitted with an air-tight cap, ProtectR® Tubes form a protective barrier impermeable to CO₂, keeping the sample pH stable and preventing acidification.

Código de Artigo: (171-0126)

Fornecedor: Merck

Descrição: Adequado para aplicações laboratoriais gerais não críticas ou como um tratamento prévio para sistemas de água ultrapura, o sistema RiOs™ 3 constitui uma solução ideal para necessidades de água para laboratório de tipo III, tais como a limpeza e o enxaguamento manuais, preparação de tampões e água de alimentação para humidificadores, autoclaves, máquinas de lavar material de vidro. Concebidos para utilizadores que procuram uma solução compacta e fácil de usar, o sistema RiOs™ 3 será altamente apreciado pela sua operação intuitiva, pelas dimensões reduzidas e pela fácil manutenção. Para os utilizadores que necessitam de aceder a água ultrapura, o sistema RiOs™ 3 é ideal como pré-tratamento de sistemas de purificação da água Synergy® ou Milli-Q®. Até 30 L/dia de água da rede de abastecimento de alta qualidade, de grau analítico (água de tipo III).

UOM: 1 * 1 unid.

Promoção

Fornecedor: Thermo Fisher Scientific

Descrição: Sulfato ferro (III) de amónio dodecahidratado 98.5-102.0% ACS

MSDS Certificados

Código de Artigo: (390-0975)

Fornecedor: Hettich

Descrição: The HettCube range of cooled incubators provide functionality and customised features. The inner chamber is made from acid-proof stainless steel (DIN 1.4301). Units only heat and cool as necessary, ensuring lower power consumption, operating costs and environmental impact. At an operating temperature of 37 °C the units consume less than 0,05 kWh. The fan is located outside the usable space, so there is a low air flow inside the chamber and a low noise level.

UOM: 1 * 1 unid.

Promoção

Código de Artigo: (461-1072)

Fornecedor: HUBER

Descrição: Estes circuladores compactos com refrigeração, são ideais para o controlo directo da temperatura entre −90 e +200 °C. O baixo volume do banho e a alta capacidade de aquecimento e resfriamento significam taxas de aquecimento e resfriamento curtas, que podem ser aumentadas usando as inserções de deslocamento opcionais. Inserções de calibração opcionais permitem que os circuladores sejam usados como banhos de calibração.

UOM: 1 * 1 unid.

Promoção

Código de Artigo: (34811-6X500ML)

Fornecedor: Honeywell Chemicals

Descrição: HYDRANAL™-Composite is a frequently used pyridine-free Karl Fischer reagent. This one-component reagent has been proving its capabilities in volumetric titration for more than thirty five years in a large range of applications in the most diverse fields of research and industry.

The one component system have the following advantages:

UOM: 1 * 3.000 mL

MSDS Promoção