Print…

Geldanamycin ≥95% (by HPLC)

Fornecedor: ENZO LIFE SCIENCES

BMLEI2800001 BMLEI2800005
ENZOBMLEI2800001EA 165 EUR
ENZOBMLEI2800001 ENZOBMLEI2800005
Geldanamycin ≥95% (by HPLC)
Geldanamycin

Potent antitumor antibiotic. Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes.


  • Yellow solid


Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against alpha-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes. 10-fold more potent than herbimycin A.


Soluble in DMSO (10 mg/mL); insoluble in water


Embalagem: Shipping temperature: Ambient

Fórmula: C₂₉H₄₀N₂O₉
Temperatura de Armazenamento: Congelador
Número MDL : MFCD00274570
Número CAS: 30562-34-6
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=5726d9690b11d4806d965873e2bfb1649fcaae60&vid=ee0d86ac38d7bab6048d691c880a8f784686ef49&prid=web&clid=SAPDAM

Encomendar


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Mais info About VWR