Procurou por: Cayman Chemical

Fornecedor: Cayman Chemical

Descrição: 4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine, pyridoxal, and pyridoxamine in and reduces growth of<i> S.</i> <i>carlsbergensis</i> cells. 4-DPD inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Certificados

Fornecedor: Cayman Chemical

Descrição: Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A₂ (PLA₂) activity (IC₅₀=40 µM in human neutrophils).

Fornecedor: Cayman Chemical

Descrição: Isomaltose is a glucose disaccharide with an α-(1 - 6) linkage, as opposed to the α-(1 - 4) linkage found in maltose. It can be liberated from dextran by dextranase and is hydrolyzed to D-glucose by isomaltase through an α-D-glucosidase-type action. Congenital sucrase-isomaltase deficiency is a rare autosomal intestinal disorder resulting from mutations affecting the gene encoding, the proprotein from which sucrase and isomaltase are produced.

Certificados

Fornecedor: Cayman Chemical

Descrição: ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).1 It contains mixed linkages (ML) with both 2'5' and 3'5' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; Item No. 17753), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 breast and CT26 colon cancer mouse xenograft models.

Fornecedor: Cayman Chemical

Descrição: Hexadecanamide is a primary fatty acid amide that is derived from palmitic acid (C16:0) and belongs to a class of important cell signaling lipids.

Código de Artigo: (CAYM501700-96)

Fornecedor: Cayman Chemical

Descrição: For the quantification of 2’3’-cGAMP in cell lysates.

UOM: 1 * 96 Tests

Promoção

Fornecedor: Cayman Chemical

Descrição: Blasticidin S is a peptidyl nucleoside antibiotic. It was first isolated from <i>S. griseochromogenes</i>. The structure of the pentahydrate form is determined using diffractometer data and, similar to the antibiotic amicetin, the hydrophilic and hydrophobic groups lie on either side of the molecule.

MSDS

Fornecedor: Cayman Chemical

Descrição: L-Sulforaphane is an isothiocyanate derived from the natural compound glucoraphanin, which is abundant in cruciferous vegetables, including broccoli. It has powerful antioxidant, anti-inflammatory, and anti-carcinogenic effects.

Código de Artigo: (CAYM10010377-1)

Fornecedor: Cayman Chemical

Descrição: Arachidonic acid

UOM: 1 * 200 µl

Promoção

Fornecedor: Cayman Chemical

Descrição: The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific research today.

Código de Artigo: (CAYM100034-1)

Fornecedor: Cayman Chemical

Descrição: Anti-COX-2 Goat Polyclonal Antibody

UOM: 1 * 1 unid.

Promoção

Fornecedor: Cayman Chemical

Descrição: Anti-Zrp Mouse Monoclonal Antibody [clone: MN-7F2]

Código de Artigo: (CAYM100000-1)

Fornecedor: Cayman Chemical

Descrição: Anti-OPTN Rabbit Polyclonal Antibody

UOM: 1 * 1 unid.

Promoção

Fornecedor: Cayman Chemical

Descrição: Dihydrocapsaicin

Fornecedor: Cayman Chemical

Descrição: 9,12-Octadecadiynoic Acid

Código de Artigo: (CAYM10008856-200)

Fornecedor: Cayman Chemical

Descrição: Anti-GnRH Chicken Polyclonal Antibody

UOM: 1 * 200 µl

Promoção