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Image Unavailable-BOSSBS-3048R-CY7

Anti-ARRB1 Rabbit Polyclonal Antibody (Cy7®)

Código de Artigo: (BOSSBS-3048R-CY7)
Fornecedor: Bioss
Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3048R-FITC

Anti-ARRB1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Código de Artigo: (BOSSBS-3048R-FITC)
Fornecedor: Bioss
Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3048R-A555

Anti-ARRB1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Código de Artigo: (BOSSBS-3048R-A555)
Fornecedor: Bioss
Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3048R-CY5.5

Anti-ARRB1 Rabbit Polyclonal Antibody (Cy5.5®)

Código de Artigo: (BOSSBS-3048R-CY5.5)
Fornecedor: Bioss
Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6071R-CY5

Anti-LRP12 Rabbit Polyclonal Antibody (Cy5®)

Código de Artigo: (BOSSBS-6071R-CY5)
Fornecedor: Bioss
Descrição: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5038R-A350

Anti-APOE Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Código de Artigo: (BOSSBS-5038R-A350)
Fornecedor: Bioss
Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5038R-CY3

Anti-APOE Rabbit Polyclonal Antibody (Cy3®)

Código de Artigo: (BOSSBS-5038R-CY3)
Fornecedor: Bioss
Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5038R-HRP

Anti-APOE Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Código de Artigo: (BOSSBS-5038R-HRP)
Fornecedor: Bioss
Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
UOM: 1 * 100 µl
Image Unavailable-MMMA7100123157

3M™ PELTOR™ X2B Earmuffs Neckband

Código de Artigo: (MMMA7100123157)
Fornecedor: 3M
Descrição: Left and right side attachment conversion kit to earmuffs to Comtac XP and Comtac XPI headsets. Twin headband design provides heat dispersion and internal stainless steel design offers consistent pressure and comfortable fit over an eight hour period.
UOM: 1 * 10 unid.
Image Unavailable-BOSSBS-0444R-A555

Anti-SLC22A17 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Código de Artigo: (BOSSBS-0444R-A555)
Fornecedor: Bioss
Descrição: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0444R-FITC

Anti-SLC22A17 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Código de Artigo: (BOSSBS-0444R-FITC)
Fornecedor: Bioss
Descrição: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13537R-A750

Anti-GPR44 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Código de Artigo: (BOSSBS-13537R-A750)
Fornecedor: Bioss
Descrição: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13537R-A647

Anti-PTGDR2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Código de Artigo: (BOSSBS-13537R-A647)
Fornecedor: Bioss
Descrição: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13537R-A488

Anti-PTGDR2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Código de Artigo: (BOSSBS-13537R-A488)
Fornecedor: Bioss
Descrição: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13537R-A350

Anti-PTGDR2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Código de Artigo: (BOSSBS-13537R-A350)
Fornecedor: Bioss
Descrição: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
UOM: 1 * 100 µl
Imagem do Produto-216-3096

Airtight, Water-Resistant Storage Boxes

Fornecedor: MULTIROIR
Descrição: These airtight boxes are designed to withstand the harshest conditions, both indoors and outdoors. When tightly closed, the boxes become completely sealed, effectively preventing moisture and dust from reaching the contents inside.

Preço sob consulta
O stock para este item é limitado. Por favor, certifique-se de que efetuou o seu login para visualizar o stock disponível. Se a call ainda é exibida e precisar de ajuda, por favor, ligue para 213 600 770
O stock para este item é limitado. Por favor, certifique-se de que efetuou o seu login para visualizar o stock disponível. Se a call está visível e precisar de ajuda, por favor, ligue para 213 600 770
Este produto é sujeito a regulamentação especifica.
Em caso de encomenda, será contactado a solicitar documentação complementar necessária e/ou obrigatória (licença, autorização ou declaração de uso final) para a continuidade do pedido. Agradecemos a vossa compreensão
Este produto é sujeito a regulamentação especifica.
Em caso de encomenda, será contactado a solicitar documentação complementar necessária e/ou obrigatória (licença, autorização ou declaração de uso final) para a continuidade do pedido. Agradecemos a vossa compreensão.
Este produto está bloqueado. Para obter mais informações, contacte a VWR através do número 213 600 770.
O produto pretendido já não se encontra disponível. O produto indicado é um substituto.
Este produto encontra-se em rutura de stock. Poderá encontrar alternativas pesquisando pelo código de artigo indicado acima. Se precisar de ajuda, por favor contacte a VWR através do 213 600 770.
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