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Descrição: Beta-Defensin 3 (BD-3), also known as DEFB-3, is a member of the defensin class of antimicrobial peptides. Beta defensins exert host defense responses against viruses, bacteria, and fungi through the binding and permeabilizing of microbial membranes. BD-3 expression is stimulated by interferon-gamma and is an important molecule during adaptive immunity. BD-3 functions to activate monocytes and mast cells, and has antibacterial functions towards Gram-negative and Gram-positive bacteria. Further, BD-3 blocks human immunodeficiency virus type 1 (HIV-1) replication through the downregulation of the HIV-1 co-receptor, CXCR4.
Código de Artigo: SHBT100-192-20UG
UOM: 1 * 20 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.
Código de Artigo: SHBT100-187-1MG
UOM: 1 * 1 mg
Fornecedor: Shenandoah Biotechnology


Descrição: Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
Código de Artigo: SHBT100-191AF-500U
UOM: 1 * 500 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells.
Código de Artigo: SHBT100-90-10UG
UOM: 1 * 10 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS).
Código de Artigo: SHBT100-111-10UG
UOM: 1 * 10 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
Código de Artigo: SHBT200-02AF-10UG
UOM: 1 * 10 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Código de Artigo: SHBT400-15-100UG
UOM: 1 * 100 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Nerve growth factor beta (β-NGF) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. β-NGF signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. β-NGF is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat β-NGF proteins are cross-reactive.
Código de Artigo: SHBT200-11-20UG
UOM: 1 * 20 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.
Código de Artigo: SHBT200-13-1MG
UOM: 1 * 1 mg
Fornecedor: Shenandoah Biotechnology


Descrição: Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.
Código de Artigo: SHBT800-05AF-25UG
UOM: 1 * 25 µG
Fornecedor: Shenandoah Biotechnology


Descrição: Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis.  PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling.  PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells.
Código de Artigo: SHBT200-54-1MG
UOM: 1 * 1 mg
Fornecedor: Shenandoah Biotechnology


Descrição: PRIME-XV IS21 SUPPLEMENT 50X 1 * 10 mL
Código de Artigo: SHBT91142
UOM: 1 * 10 mL
Fornecedor: Shenandoah Biotechnology

Novo produto


Descrição: ANIMAL-FREE MOUSE CNTF 1 * 1 mg
Código de Artigo: SHBT200-90AF-1MG
UOM: 1 * 1 mg
Fornecedor: Shenandoah Biotechnology


Descrição: PRIME-XV FREEZIS DMSO-FREE 1 * 10 mL
Código de Artigo: SHBT91140-10ML
UOM: 1 * 10 mL
Fornecedor: Shenandoah Biotechnology

Novo produto


Descrição: CLICK'S MEDIUM EHAA 1 * 500 mL
Código de Artigo: SHBT9195
UOM: 1 * 500 mL
Fornecedor: Shenandoah Biotechnology

Novo produto


Descrição: PRIME-XV FREEZIS DMSO-FREE 1 * 100 mL
Código de Artigo: SHBT91140-100ML
UOM: 1 * 100 mL
Fornecedor: Shenandoah Biotechnology

Novo produto


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