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Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Código de Artigo: BOSSBS-3048R-A488
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Código de Artigo: BOSSBS-3048R-HRP
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Left and right side attachment conversion kit to earmuffs to Comtac XP and Comtac XPI headsets. Twin headband design provides heat dispersion and internal stainless steel design offers consistent pressure and comfortable fit over an eight hour period.
Código de Artigo: MMMA7100123157
UOM: 1 * 10 unid.
Fornecedor: 3M


Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Código de Artigo: BOSSBS-5039R-A680
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Código de Artigo: BOSSBS-4892R-CY5.5
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Código de Artigo: BOSSBS-4892R-CY7
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Código de Artigo: BOSSBS-2200R-A488
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Código de Artigo: BOSSBS-4892R-HRP
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: This range of euro containers are made entirely from recycled polypropylene and adhere to the guidelines of the 'Der Blaue Engel' ecological label. Suitable for use in industry, handling, and automated transportation, they remain resilient to impacts and temperature variations. They can be stacked and nested without the risk of falling.
Código de Artigo: 216-2997
UOM: 1 * 1 unid.
Fornecedor: VWR Collection


Descrição: These airtight boxes are designed to withstand the harshest conditions, both indoors and outdoors. When tightly closed, the boxes become completely sealed, effectively preventing moisture and dust from reaching the contents inside.
Código de Artigo: 216-3096
UOM: 1 * 6 unid.
Fornecedor: MULTIROIR


Descrição: Matrix™ tri-coded tubes combine the 2D matrix code with an improved linear and human-readable barcode.
Código de Artigo: 479-2456
UOM: 1 * 480 unid.
Fornecedor: THERMO MATRIX TECHNOLOGIES

Environmentally Preferable


Descrição: Pure and ultra pure water system, Filtro de ventilação para tanque interno, evita a contaminação da água pura armazenada em tanques de armazenamento interno de 6/10 l
Código de Artigo: 171-0550
UOM: 1 * 2 unid.
Fornecedor: Merck


Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Código de Artigo: BOSSBS-3048R-CY3
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Código de Artigo: BOSSBS-3048R-CY5
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Código de Artigo: BOSSBS-6071R-CY5
UOM: 1 * 100 µl
Fornecedor: Bioss


Descrição: The BD Q-Syte™ Needle-free connector has a split septum design that complies with the guidelines for reducing catheter-related bloodstream infection (CRBSI) rates set by the Centers for Disease Control and Prevention (CDC) and the International Nosocomial Infection Control Consortium (INICC).
Código de Artigo: BDAM380510
UOM: 1 * 9.000 unid.
Fornecedor: BD Medical


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