Procurou por: Centr\u00EDfugas

Código de Artigo: (BOSSBS-0087R-A647)

Fornecedor: Bioss

Descrição: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

UOM: 1 * 100 µl

Promoção

Fornecedor: DWK Life Sciences

Descrição: Aluminum seals (unlined) are available in a wide range of styles and sizes.

Fornecedor: VACUUBRAND

Descrição: These adapting centring rings for small flange connections with sealing ring made of FKM.

Código de Artigo: (USBE5072)

Fornecedor: USBECK Laborgeräte

Descrição: Mesh from galvanised steel wire.

UOM: 1 * 1 unid.

Novo produto Promoção

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: DURAN®, vidro borosilicato, com gargalo lateral angulado, transparente.

Fornecedor: DRUMMOND

Descrição: Stainless steel/PTFE manifolds allow multiple test positions to be fed, rinsed, or aspirated quickly and easily.

Código de Artigo: (BOSSBS-3948R-A680)

Fornecedor: Bioss

Descrição: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal centre in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarisation by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.

UOM: 1 * 100 µl

Promoção

Código de Artigo: (PPSA3500095)

Fornecedor: PFENNIG REINIGUNGSTECHNIK

Descrição: Carrinhos, Holder frame for Clino PlusBox, electropolished stainless steel, fix PlusBox at center

UOM: 1 * 1 unid.

Promoção

Fornecedor: GLASWARENFABRIK KARL HECHT

Descrição: PTFE coated, magnetic stirring bars.

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: De vidro borosilicato DURAN®, com colos laterais inclinados, clara.

Código de Artigo: (ICNA08642771)

Fornecedor: MP Biomedicals

Descrição: The ImmunO™ Micro-Ouchterlony Plate is designed for specific but low affinity antisera. Such antisera require properly spaced wells and polyethylene glycol in the agarose for optimal immunoprecipitation. Each plate contains 8 ouchterlony patterns consisting of a centre well and 6 outer wells. The maximum sample volume is 10 µl in any of the wells.

UOM: 1 * 5 unid.

Certificados Promoção

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: DURAN®, borosilicate glass, with parallel side neck.

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: Glass filter discs centred with unfused rim.

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: DURAN®, borosilicate glass, clear.

Fornecedor: Lenz Laborglas GmbH & CO.KG

Descrição: DURAN®, vidro borosilicato, com dois gargalos laterais paralelos, transparente.

Código de Artigo: (BOSSBS-2734R-A750)

Fornecedor: Bioss

Descrição: Transcriptional repressor mainly required for germinal centre (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

UOM: 1 * 100 µl

Promoção