Procurou por: Akt+inhibitor+VIII

Código de Artigo: (TCIAA3153-100MG)

Fornecedor: TCI

Descrição: Akt inhibitor VIII ≥97.0% (by HPLC)

UOM: 1 * 100 mg

Promoção

Fornecedor: ENZO LIFE SCIENCES

Descrição: Potent inhibitor of Akt1, Akt2 and Akt3 activity.

Novo produto

Fornecedor: ENZO LIFE SCIENCES

Descrição: HDAC6 inhibitor

Novo produto

Fornecedor: ENZO LIFE SCIENCES

Descrição: Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.

Novo produto

Código de Artigo: (ENZOADIEKS400A)

Fornecedor: ENZO LIFE SCIENCES

Descrição: This is a non-radioactive Akt kinase activity assay, providing a safe, rapid and reliable method for the screening of inhibitors or activators of Akt and for quantitating the activity of Akt in purified or partially purified enzyme preparations. The Akt Kinase activity kit is based on a solid phase enzyme immunoassay (EIA) that utilizes a specific synthetic peptide as a substrate for Akt and a polyclonal antibody that recognizes the phosphorylated form of the substrate. The assay is designed for the analysis of Akt (1, 2, 3) activity in the solution phase.

UOM: 1 * 1 KIT

Novo produto Promoção

Código de Artigo: (ENZOENZCHM1260001)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Selective inhibitor of Akt (PKB).

UOM: 1 * 1 mg

Novo produto Promoção

Fornecedor: ENZO LIFE SCIENCES

Descrição: Akt inhibitor

Novo produto

Fornecedor: ENZO LIFE SCIENCES

Descrição: Akt inhibitor

Novo produto

Código de Artigo: (ENZOALX260155M001)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Selective cell permeable inhibitor of PKCzeta. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.

UOM: 1 * 1 mg

Novo produto Promoção

Código de Artigo: (J64554.MA)

Fornecedor: Thermo Fisher Scientific

Descrição: A cell-permeable, potent, and selective inhibitor of GSK-3beta.

UOM: 1 * 10 mg

MSDS Promoção

Fornecedor: ENZO LIFE SCIENCES

Descrição: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

Novo produto

Código de Artigo: (506163-5MG)

Fornecedor: Merck Millipore (Calbiochem‎)

Descrição: p38 MAP Kinase Inhibitor VIII ≥97% (por HPLC), Calbiochem®, Sigma-Aldrich®

UOM: 1 * 5 mg

Promoção

Código de Artigo: (ENZOADI905773100)

Fornecedor: ENZO LIFE SCIENCES

Descrição: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified to date (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

UOM: 1 * 100 µG

Novo produto Promoção

Fornecedor: ENZO LIFE SCIENCES

Descrição: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

Novo produto

Código de Artigo: (ENZOALX350312M025)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.

UOM: 1 * 25 mg

Novo produto Promoção

Código de Artigo: (ENZOADI905643100)

Fornecedor: ENZO LIFE SCIENCES

Descrição: Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes.

UOM: 1 * 100 µG

Novo produto Promoção