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Anti-PTH Mouse Monoclonal Antibody [clone: 3H9 PTH/1175]

Fornecedor: Biotium
BNUB1236-500 BNUB1236-100
BTIUBNUB1236-500EA 511 EUR
BTIUBNUB1236-500 BTIUBNUB1236-100
Anti-PTH Mouse Monoclonal Antibody [clone: 3H9 PTH/1175]
Anticorpos
The epitope of this MAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

  • Purified

Type: Primary
Antigen: PTH
Clonality: Monoclonal
Clone: 3H9 PTH/1175
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
Encomendar

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