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Anti-TLR4 Mouse Monoclonal Antibody (CF770) [clone: TLR4/230]

Fornecedor: Biotium
BNC700230-500 BNC700230-100
BNC700230-500EA 560 EUR
BNC700230-500 BNC700230-100
Anti-TLR4 Mouse Monoclonal Antibody (CF770) [clone: TLR4/230]
Anticorpos
This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Type: Primary
Antigen: TLR4
Clonality: Monoclonal
Clone: TLR4/230
Conjugation: CF770
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Dog, Guinea Pig, Human, Monkey, Pig, Rat
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