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Anti-TFRC Rabbit Polyclonal Antibody (Cy3®)

Fornecedor: Bioss
BS-0988R-CY3
BOSSBS-0988R-CY3EA 900 EUR
BOSSBS-0988R-CY3
Anti-TFRC Rabbit Polyclonal Antibody (Cy3®)
Anticorpos
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal bindingMais informação do produto
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